Recombinant Lake Victoria marburgvirus Polymerase cofactor VP35 (VP35), Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975)), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 43.7kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Lake Victoria marburgvirus Polymerase cofactor VP35 (VP35)

Recombinant Lake Victoria marburgvirus Polymerase cofactor VP35 (VP35) — Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Purity >95%.

SKU: BCRECP-004736 Categories: ,
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Product Specifications

Product SkuBCRECP-004736
Product DescriptionRecombinant Lake Victoria marburgvirus Polymerase cofactor VP35 (VP35) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-329aa. [Accession | Q6UY68].
Uniprot No.Q6UY68
Gene NamesVP35
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-329aa
SpeciesLake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight43.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Part of the external layer of the nucleocapsid, likely tethering the nucleocapsid to the matrix and membrane.

Biological Context

Subcellular Location: Virion; Host cytoplasm

Product Specifications

Recombinant Lake Victoria marburgvirus Polymerase cofactor VP35 (VP35) is a recombinant protein from Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975)), expressed in E.coli, covering amino acids 1-329aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 43.7kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Part of the external layer of the nucleocapsid, likely tethering the nucleocapsid to the matrix and membrane (By similarity)

Subcellular Location

Virion; Host cytoplasm

Subunit

Homotetramer. Interacts with L polymerase; this complex constitutes a functional polymerase complex. Homomultimerization via the coiled coil domain is a prerequisite for binding to L. Found in a trimeric complex in which VP35 bridges L and the nucleoprotein (By similarity). Interacts with NP (PubMed:28566377, PubMed:28659479). Disrupts innate immune signaling in infected host cell (By similarity)

Gene: VP35  |  Organism: Lake Victoria marburgvirus (strain Ozolin-75)  |  Synonyms: Marburg VP35

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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