Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) (Active), Macaca mulatta (Rhesus macaque), Mammalian cell, C-terminal mFc-tagged, 37.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) (Active)

Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) (Active) — Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Purity >95%.

SKU: BCACP-000435 Categories: ,
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Product SKUBCACP-000435
Product DescriptionRecombinant Rhesus macaque C-C motif chemokine 17 (CCL17) protein is expressed from Mammalian cell with C-terminal mFc-tagged. It contains 24-94aa. [Accession | Q8HYP9].
Uniprot No.Q8HYP9
Gene NamesCCL17
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-94aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoC-terminal mFc-tagged
Molecular weight37.4 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/mL can bind Anti-CSF1 recombinant antibody . The EC50 is 4.291-4.988 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/mL can bind Human CSF1R protein . The EC50 is 37.37-43.34 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesC-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; TARC

Function

Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface.

Product Specifications

Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 24-94aa, with C-terminal mFc-tagged tag, molecular weight 37.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/mL can bind Anti-CSF1 recombinant antibody . The EC50 is 4.291-4.988 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/mL can bind Human CSF1R protein . The EC50 is 37.37-43.34 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation (By similarity). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity)

Gene: CCL17  |  Organism: Macaca mulatta

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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