Recombinant Macaca mulatta Erythropoietin receptor (EPOR), partial

Recombinant Macaca mulatta Erythropoietin receptor (EPOR), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >95%.

SKU: BCRECP-002652 Category:

Product Specifications

Product SkuBCRECP-002652
Product DescriptionRecombinant Macaca mulatta Erythropoietin receptor (EPOR) Protein is expressed from Yeast with C-terminal 10xHis-tagged. It contains 26-250aa. [Accession | F7GNY3].
Uniprot No.F7GNY3
Gene NamesEPOR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region26-250aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoC-terminal 10xHis-tagged
Molecular weight26.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade.

Product Specifications

Recombinant Macaca mulatta Erythropoietin receptor (EPOR), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >95%. Suitable for ELISA and Western Blot applications.

Catalog number: BCRECP-002652.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Subunit

Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein SH2B2, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL. Interacts with INPP5D/SHIP1. SH2B2 binding inhibits the JAK-STAT signaling. Interacts with RHEX; this interaction occurs in a erythropoietin (EPO)-dependent manner. Interacts with ATXN2L

Gene: EPOR  |  Organism: Macaca mulatta

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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