Recombinant Macaca mulatta Interleukin-10 (IL10), Macaca mulatta (Rhesus macaque), Mammalian cell, N-terminal DEEP1-tagged and C-terminal 6xHis-tagged, 32.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Macaca mulatta Interleukin-10 (IL10)

Recombinant Macaca mulatta Interleukin-10 (IL10) — Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Purity >90%.

SKU: BCRECP-003107 Categories: ,
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Product Specifications

Product SkuBCRECP-003107
Product DescriptionRecombinant Macaca mulatta Interleukin-10 (IL10) Protein is expressed from Mammalian cell with N-terminal DEEP1-tagged and C-terminal 6xHis-tagged. It contains 19-178aa. [Accession | P51496].
Uniprot No.P51496
Gene NamesIL10
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region19-178aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoN-terminal DEEP1-tagged and C-terminal 6xHis-tagged
Molecular weight32.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Macaca mulatta Interleukin-10 (IL10) is a recombinant protein from Macaca mulatta (Rhesus macaque), expressed in Mammalian cell, covering amino acids 19-178aa, with N-terminal DEEP1-tagged and C-terminal 6xHis-tagged tag, molecular weight 32.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)

Subcellular Location

Secreted

Subunit

Homodimer. Interacts with IL10RA and IL10RB

Gene: IL10  |  Organism: Macaca mulatta  |  Synonyms: Cytokine synthesis inhibitory factor

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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