Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active), Macaca mulatta (Rhesus macaque), Mammalian cell, C-terminal 10xHis-tagged, 39.5 kDa, purity >95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
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Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active)

Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active) — Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. Purity >95%.

SKU: BCACP-000513 Categories: ,
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Product SKUBCACP-000513
Product DescriptionRecombinant Rhesus macaque Interleukin-6 receptor subunit alpha (IL6R), Partial protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 20-365aa. [Accession | A0A5F8AUE5].
Uniprot No.A0A5F8AUE5
Gene NamesIL6R
PurityGreater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region20-365aa
SpeciesMacaca mulatta (Rhesus macaque)
Tag InfoC-terminal 10xHis-tagged
Molecular weight39.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Human CSF3 ). The EC50 is 33.76-58.81 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Anti-CSF3R recombinant antibody . The EC50 is 2.544-2.926 ng/mL.;Human CSF3 ) captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.123 nM as detected by MetaSPR Assay (WeSPRTM 200).;CSF3R Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.157 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-6 receptor subunit alpha; IL-6R 1

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases.

Product Specifications

Recombinant Macaca mulatta Interleukin-6 receptor subunit alpha (IL6R), Partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 20-365aa, with C-terminal 10xHis-tagged tag, molecular weight 39.5 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Human CSF3 ). The EC50 is 33.76-58.81 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human CSF3R at 2 μg/mL can bind Anti-CSF3R recombinant antibody . The EC50 is 2.544-2.926 ng/mL.;Human CSF3 ) captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.123 nM as detected by MetaSPR Assay (WeSPRTM 200).;CSF3R Recombinant Monoclonal Antibody captured on Protein A Chip can bind Recombinant Human CSF3R with an affinity constant of 0.157 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis

Gene: IL6R  |  Organism: Macaca mulatta

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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