Recombinant Macrovipera lebetina obtusa Disintegrin obtustatin, Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa), Yeast, C-terminal 6xHis-Myc-tagged, 8.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Macrovipera lebetina obtusa Disintegrin obtustatin

Recombinant Macrovipera lebetina obtusa Disintegrin obtustatin — Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. Purity >85%.

SKU: BCRECP-003788 Category:
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Product Specifications

Product SkuBCRECP-003788
Product DescriptionRecombinant Macrovipera lebetina obtusa Disintegrin obtustatin Protein is expressed from Yeast with C-terminal 6xHis-Myc-tagged. It contains 1-41aa. [Accession | P83469].
Uniprot No.P83469
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-41aa
SpeciesMacrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
Tag InfoC-terminal 6xHis-Myc-tagged
Molecular weight8.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Macrovipera lebetina obtusa Disintegrin obtustatin is a recombinant protein from Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa), expressed in Yeast, covering amino acids 1-41aa, with C-terminal 6xHis-Myc-tagged tag, molecular weight 8.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin. It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0.5 nM, respectively. Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half. Is 25-fold less potent than viperistatin

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Subunit

Monomer

Organism: Macrovipera lebetina obtusa

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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