Recombinant Measles virus Hemagglutinin glycoprotein (H) Protein, Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus), in vitro E.coli expression system, N-terminal 10xHis-tagged, 75.4kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Measles virus Hemagglutinin glycoprotein (H) Protein

Recombinant Measles virus Hemagglutinin glycoprotein (H) Protein — Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppr… Purity >85%.

SKU: BCRECP-00065TM Categories: ,
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Product Specifications

Uniprot No.P35971
Gene NamesH
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-617aa
SpeciesMeasles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
Tag InfoN-terminal 10xHis-tagged
Molecular weight75.4kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection. In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.

Biological Context

Subcellular Location: Virion membrane (Single-pass type II membrane protein); Host cell membrane (Single-pass type II membrane protein)

Product Specifications

Recombinant Measles virus Hemagglutinin glycoprotein (H) Protein is a recombinant protein from Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus), expressed in in vitro E.coli expression system, covering amino acids 1-617aa, with N-terminal 10xHis-tagged tag, molecular weight 75.4kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Attaches the virus to the human SLAMF1/CD150 receptor for entry into host dendritic cells, macrophages, activated memory T cells and naive or memory B cells, thereby explaining the long immunosuppression that follows infection (By similarity). In the respiratory airways, binds to the NECTIN4 receptor for entry into the host cell (By similarity). Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). The vaccine and laboratory-adapted strains use host CD46 as an alternate receptor (PubMed:12029158). The high degree of interaction between H and CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity)

Subcellular Location

Virion membrane (Single-pass type II membrane protein); Host cell membrane (Single-pass type II membrane protein)

Subunit

Homodimer; disulfide-linked (By similarity). Further forms homotetramer (dimer of dimers) (By similarity). Interacts (via C-terminus) with human NECTIN4 (via N-terminus); this interaction allows attachment to the respiratory epithelium and viral entry (By similarity). Interacts (via C-terminus) with human SLAMF1/CD150 (via N-terminus); this interaction allows attachment and viral entry into the CD150-expressing immune cells (Probable). Interacts with human CD46 antigen (PubMed:12029158)

Gene: H  |  Organism: Measles virus (strain Edmonston-AIK-C vaccine)

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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