Recombinant Mouse Aquaporin-4 (Aqp4)-VLPs Protein, Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 35.9kDa, purity >The purity information is not available for VLPs proteins.
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Recombinant Mouse Aquaporin-4 (Aqp4)-VLPs Protein

Recombinant Mouse Aquaporin-4 (Aqp4)-VLPs Protein — Forms a water-specific channel. Purity The purity information is not available for VLPs proteins..

SKU: BCRECP-00441TM Categories: ,
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Product Specifications

Uniprot No.P55088
Gene NamesAqp4
PurityThe purity information is not available for VLPs proteins.
Expression SystemMammalian cell
Expression Region1-323aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight35.9kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Basolateral cell membrane (Multi-pass membrane protein); Endosome membrane; Cell membrane, sarcolemma (Multi-pass membrane protein); Cell projection
Tissue Specificity: Detected in brain cortex, especially around cortical blood vessels, and subjacent to pia, with lower levels in parenchymal membranes. Detected in ependymal and astroglial cells in brain. Detected in supporting Hensen's cells, inner sulcus cells and Claudius cells in the inner ear. Detected in skeletal muscle. Detected in gastric parietal cells. Detected in principal cells in collecting ducts in kidney medulla (at protein level). Detected in brain, heart and skeletal muscle

Product Specifications

Recombinant Mouse Aquaporin-4 (Aqp4)-VLPs Protein is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 1-323aa, with C-terminal 10xHis-tagged tag, molecular weight 35.9kDa, purity The purity information is not available for VLPs proteins.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Forms a water-specific channel (PubMed:18286643, PubMed:8660998, PubMed:9276712). Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30557661, PubMed:30561329). Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661). Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329). Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Basolateral cell membrane (Multi-pass membrane protein); Endosome membrane; Cell membrane, sarcolemma (Multi-pass membrane protein); Cell projection

Tissue Specificity

Detected in brain cortex, especially around cortical blood vessels, and subjacent to pia, with lower levels in parenchymal membranes (PubMed:27751903). Detected in ependymal and astroglial cells in brain (PubMed:22896675, PubMed:27751903, PubMed:8660998, PubMed:9276712). Detected in supporting Hensen's cells, inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in skeletal muscle (PubMed:29055082). Detected in gastric parietal cells (PubMed:10915655). Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:16641094, PubMed:9276712). Detected in brain, heart and skeletal muscle (PubMed:8660998)

Subunit

Homotetramer. The tetramers can form oligomeric arrays in membranes. The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain. Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion (By similarity). Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1 (By similarity)

Gene: Aqp4  |  Organism: Mus musculus  |  Synonyms: Mercurial-insensitive water channel; WCH4
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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