Recombinant Mouse Carnosine N-methyltransferase (Carnmt1), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-SUMO-tagged, 54.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Mouse Carnosine N-methyltransferase (Carnmt1), partial

Recombinant Mouse Carnosine N-methyltransferase (Carnmt1), partial — Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. Purity >85%.

SKU: BCRECP-002291 Categories: ,
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Product Specifications

Product SkuBCRECP-002291
Product DescriptionRecombinant Mouse Carnosine N-methyltransferase (Carnmt1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 50-400aa. [Accession | Q80UY1].
Uniprot No.Q80UY1
Gene NamesCarnmt1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region50-400aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight54.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover. Additionally, it methylates the dipeptide carnosine (beta-alanyl-L-histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle.

Biological Context

Subcellular Location: Cytoplasm, cytosol; Nucleus

Product Specifications

Recombinant Mouse Carnosine N-methyltransferase (Carnmt1), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 50-400aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 54.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover (PubMed:37612136). Additionally, it methylates the dipeptide carnosine (beta-alanyl-L-histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle. Acts also on other L-histidine-containing di- and tripeptides, such as Gly-Gly-His, Gly-His, and homocarnosine (GABA-His) (By similarity)

Subcellular Location

Cytoplasm, cytosol; Nucleus

Subunit

Homodimer. Each monomer accommodates one molecule of carnosine in its active pocket, precisely anchoring the histidine imidazole ring such that only N1 is exposed and deprotonated for methylation

Gene: Carnmt1  |  Organism: Mus musculus  |  Synonyms: Carnosine N-methyltransferase

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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