Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 29.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial

Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial — Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. Purity >85%.

SKU: BCRECP-002409 Category:
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Product Specifications

Product SkuBCRECP-002409
Product DescriptionRecombinant Mouse Collagen alpha-2 (IV) chain (Col4a2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1481-1707aa. [Accession | P08122].
Uniprot No.P08122
Gene NamesCol4a2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1481-1707aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight29.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.

Biological Context

Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane

Product Specifications

Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1481-1707aa, with N-terminal 6xHis-tagged tag, molecular weight 29.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity)

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

Subunit

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (PubMed:17324935)

Gene: Col4a2  |  Organism: Mus musculus
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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