Recombinant Mouse Complement receptor type 2 (Cr2), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 18.1kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Complement receptor type 2 (Cr2), partial

Recombinant Mouse Complement receptor type 2 (Cr2), partial — Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. Purity >90%.

SKU: BCRECP-002428 Category:
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Product Specifications

Product SkuBCRECP-002428
Product DescriptionRecombinant Mouse Complement receptor type 2 (Cr2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 12-140aa. [Accession | P19070].
Uniprot No.P19070
Gene NamesCr2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region12-140aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight18.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: B-lymphocytes

Product Specifications

Recombinant Mouse Complement receptor type 2 (Cr2), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 12-140aa, with N-terminal 6xHis-tagged tag, molecular weight 18.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

B-lymphocytes

Subunit

Interacts (via Sushi domain 1 and 2) with C3. Interacts with CD19. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts (via Sushi domain 1 and 2) with FCER2 (via the C-terminus). Interacts with CD23. Interacts with FCRL5. Interacts with CR1. Interacts with INFNA1

Gene: Cr2  |  Organism: Mus musculus  |  Synonyms: Complement C3d receptor
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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