Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial, Mus musculus (Mouse), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 28.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial

Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial — Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Purity >90%.

SKU: BCRECP-002654 Categories: , ,
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Product Specifications

Product SkuBCRECP-002654
Product DescriptionRecombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 731-930aa. [Accession | Q9EQH2].
Uniprot No.Q9EQH2
Gene NamesErap1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region731-930aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight28.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules.

Product Specifications

Recombinant Mouse Endoplasmic reticulum aminopeptidase 1 (Erap1), partial — Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Purity >90%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity)

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type II membrane protein)

Subunit

Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX (By similarity)

Gene: Erap1  |  Organism: Mus musculus  |  Synonyms: ARTS-1; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; VEGF-induced aminopeptidase

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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