Recombinant Mouse Gasdermin-D (Gsdmd), partial, Mus musculus (Mouse), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 30.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Gasdermin-D (Gsdmd), partial

Recombinant Mouse Gasdermin-D (Gsdmd), partial — Produced by the cleavage by papain allergen. Purity >90%.

SKU: BCRECP-002928 Category:
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Product Specifications

Product SkuBCRECP-002928
Product DescriptionRecombinant Mouse Gasdermin-D (Gsdmd) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 277-487aa. [Accession | Q9D8T2].
Uniprot No.Q9D8T2
Gene NamesGsdmdc1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region277-487aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight30.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Produced by the cleavage by papain allergen. After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response.

Biological Context

Subcellular Location: Cytoplasm, cytosol
Tissue Specificity: Highly expressed in brain endothelial cells

Product Specifications

Recombinant Mouse Gasdermin-D (Gsdmd), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 277-487aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 30.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35749514, PubMed:35794369)

Subcellular Location

Cytoplasm, cytosol

Tissue Specificity

Highly expressed in brain endothelial cells

Subunit

Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane (PubMed:34289345). Homooligomerization is promoted by the mTORC1 complex in macrophages (PubMed:34289345). In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor (PubMed:26611636). Although this recruitment is also observed in the absence of PYCARD, it is more efficient in its presence (PubMed:26611636)

Gene: Gsdmd  |  Organism: Mus musculus  |  Synonyms: Gasdermin domain-containing protein 1
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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