Recombinant Mouse Granzyme A (Gzma), Mus musculus (Mouse), E.coli, N-terminal 6xHis-B2M-tagged, 39.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Granzyme A (Gzma)

Recombinant Mouse Granzyme A (Gzma) — Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Purity >90%.

SKU: BCRECP-002949 Category:
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Product Specifications

Product SkuBCRECP-002949
Product DescriptionRecombinant Mouse Granzyme A (Gzma) Protein is expressed from E.coli with N-terminal 6xHis-B2M-tagged. It contains 29-260aa. [Accession | P11032].
Uniprot No.P11032
Gene NamesGzma
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-260aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-B2M-tagged
Molecular weight39.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity.

Product Specifications

Recombinant Mouse Granzyme A (Gzma) is a recombinant protein, expressed in E.coli, covering amino acids 29-260aa, with N-terminal 6xHis-B2M-tagged tag, molecular weight 39.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3555842). It cleaves after Lys or Arg (By similarity). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (By similarity). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity)

Gene: Gzma  |  Organism: Mus musculus

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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