Recombinant Mouse Integrin beta-6 (Itgb6), partial, Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 76.3kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Integrin beta-6 (Itgb6), partial

Recombinant Mouse Integrin beta-6 (Itgb6), partial — Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. Purity >95%.

SKU: BCRECP-003196 Category:
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Product Specifications

Product SkuBCRECP-003196
Product DescriptionRecombinant Mouse Integrin beta-6 (Itgb6) Protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-708aa. [Accession | Q9Z0T9].
Uniprot No.Q9Z0T9
Gene NamesItgb6
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-708aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight76.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell junction, focal adhesion
Tissue Specificity: Expressed in cardiomyocytes in the heart (at protein level)

Product Specifications

Recombinant Mouse Integrin beta-6 (Itgb6), partial is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 22-708aa, with C-terminal 10xHis-tagged tag, molecular weight 76.3kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell junction, focal adhesion

Tissue Specificity

Expressed in cardiomyocytes in the heart (at protein level)

Subunit

Heterodimer of an alpha and a beta subunit (PubMed:10025398). Interacts with FLNB (By similarity). Interacts with HAX1 (By similarity). ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398)

Gene: Itgb6  |  Organism: Mus musculus
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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