Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 28.7kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial

Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial — Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Purity >85%.

SKU: BCRECP-003055 Categories: ,
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Product Specifications

Product SkuBCRECP-003055
Product DescriptionRecombinant Mouse Interferon-activable protein 204 (Ifi204) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 216-417aa. [Accession | P0DOV2].
Uniprot No.P0DOV2
Gene NamesIfi204
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region216-417aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity. Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway. Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release.

Biological Context

Subcellular Location: Nucleus; Nucleus, nucleolus; Cytoplasm
Tissue Specificity: Present in osteoblasts (at protein level)

Product Specifications

Recombinant Mouse Interferon-activable protein 204 (Ifi204), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 216-417aa, with N-terminal 6xHis-tagged tag, molecular weight 28.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation

Subcellular Location

Nucleus; Nucleus, nucleolus; Cytoplasm

Tissue Specificity

Present in osteoblasts (at protein level)

Subunit

Interacts with UBTF. Interacts with RUNX2. Interacts with ID1, ID2 and ID3. Interacts with STING (PubMed:28529930)

Gene: Ifi204  |  Organism: Mus musculus  |  Synonyms: Interferon-inducible protein p204
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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