Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 59.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial

Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial — Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31. Purity >85%.

SKU: BCRECP-003152 Categories: ,
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Product Specifications

Product SkuBCRECP-003152
Product DescriptionRecombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 19-499aa. [Accession | Q8K5B1].
Uniprot No.Q8K5B1
Gene NamesIl31ra
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region19-499aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight59.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31. Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity. Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Presynaptic cell membrane; Cell projection, axon
Tissue Specificity: Expressed in a subset of dorsal root ganglia neurons. Expressed in spinal cord and trigeminal ganglion (at protein level). Expressed in skin, testis, bone marrow and thymus

Product Specifications

Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 19-499aa, with N-terminal 6xHis-tagged tag, molecular weight 59.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Presynaptic cell membrane; Cell projection, axon

Tissue Specificity

Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896)

Subunit

Interacts with JAK1 and STAT3

Gene: Il31ra  |  Organism: Mus musculus  |  Synonyms: Gp130-like monocyte receptor; Gp130-like receptor; Novel cytokine receptor 10; ZcytoR17
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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