Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial

Function

Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Presynaptic cell membrane; Cell projection, axon

Tissue Specificity

Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896)

Subunit

Interacts with JAK1 and STAT3

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• Dillon S.R. et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. — Nat. Immunol. (2004)
• Nomura H. et al. Polymorphism between C57BL/6 and Balb/c in the novel cytokine receptor NR10. (APR-)
• Carninci P. et al. The transcriptional landscape of the mammalian genome. — Science (2005)
• Church D.M. et al. Lineage-specific biology revealed by a finished genome assembly of the mouse. — PLoS Biol. (2009)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Bando T. et al. Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns. — Neuroscience (2006)
• Broxmeyer H.E. et al. Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31. — Exp. Hematol. (2007)