Recombinant Mouse Interleukin-9 protein (Il9) (Active), Mus musculus (Mouse), E.Coli, Tag-Free, 14.2 kDa, purity >>97% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-9 protein (Il9) (Active)

Recombinant Mouse Interleukin-9 protein (Il9) (Active) — Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Purity >97%.

SKU: BCACP-000717 Categories: ,
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Product SKUBCACP-000717
Product DescriptionRecombinant Mouse Interleukin-9 protein (Il9) protein is expressed from E.Coli with Tag-Free. It contains 19-144aa. [Accession | P15247].
Uniprot No.P15247
Gene NamesIl9
Purity>97% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region19-144aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight14.2 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesIl9; Interleukin-9; IL-9; Cytokine P40; T-cell growth factor P40

Function

Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Mouse Interleukin-9 protein (Il9) (Active) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 19-144aa, with Tag-Free tag, molecular weight 14.2 kDa, purity >97% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327)

Subcellular Location

Secreted

Subunit

Interacts with IL9R (PubMed:2145361). Interacts with IL2RG (PubMed:7718508)

Gene: Il9  |  Organism: Mus musculus  |  Synonyms: Cytokine P40; T-cell growth factor P40
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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