Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1), Mus musculus (Mouse), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 48.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1)

Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1) — Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Purity >90%.

SKU: BCRECP-003268 Category:
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Product Specifications

Product SkuBCRECP-003268
Product DescriptionRecombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-357aa. [Accession | P11260].
Uniprot No.P11260
Gene NamesLire1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-357aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight48.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Biological Context

Subcellular Location: Nucleus, nucleolus; Cytoplasm; Cytoplasm, Cytoplasmic ribonucleoprotein granule; Cytoplasm, Stress granule
Tissue Specificity: Expressed in meiotic spermatocytes and in the cerebellum (at protein level)

Product Specifications

Recombinant Mouse LINE-1 retrotransposable element ORF1 protein (Lire1) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-357aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 48.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded

Subcellular Location

Nucleus, nucleolus; Cytoplasm; Cytoplasm, Cytoplasmic ribonucleoprotein granule; Cytoplasm, Stress granule

Tissue Specificity

Expressed in meiotic spermatocytes and in the cerebellum (at protein level)

Subunit

Homotrimer (via coiled coil domain). May also form larger homooligomers. Interacts with Tex19.1 and UBR2 (PubMed:28806172). Interacts with MOV10 (PubMed:28662698)

Gene: Lire1  |  Organism: Mus musculus  |  Synonyms: LINE retrotransposable element 1; LINE1 retrotransposable element 1; Transposase element L1Md-A101/L1Md-A102/L1Md-A2
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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