Recombinant Mouse Lysine-specific demethylase 6A (Kdm6a), partial Protein, Mus musculus (Mouse), E.coli, C-terminal 6xHis-tagged, 25.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Lysine-specific demethylase 6A (Kdm6a), partial Protein

Recombinant Mouse Lysine-specific demethylase 6A (Kdm6a), partial Protein — Histone demethylase that specifically demethylates ‘Lys-27’ of histone H3, thereby playing a central role in histone code. Purity >90%.

SKU: BCRECP-00451TM Category:
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Product Specifications

Uniprot No.O70546
Gene NamesKdm6a
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1095-1258aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight25.7kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Expressed in brain, heart and spleen

Product Specifications

Recombinant Mouse Lysine-specific demethylase 6A (Kdm6a), partial Protein is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1095-1258aa, with C-terminal 6xHis-tagged tag, molecular weight 25.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (PubMed:21095589)

Subcellular Location

Nucleus

Tissue Specificity

Expressed in brain, heart and spleen

Subunit

Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with TLE1 (PubMed:9854018). Interacts with SUPT6H (PubMed:23503590). Interacts with SMARCA4 (PubMed:21095589). Interacts with PROSER1 (By similarity)

Gene: Kdm6a  |  Organism: Mus musculus  |  Synonyms: Histone demethylase UTX; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; [histone H3]-trimethyl-L-lysine(27) demethylase 6A
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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