Recombinant Mouse Mu-type opioid receptor (Oprm1) Protein

Function

Isoform 9 is involved in morphine-induced scratching and seems to cross-activate GRPR in response to morphine

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cell projection, axon; Perikaryon; Cell projection, dendrite; Endosome

Subunit

Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:10842167, PubMed:12270145, PubMed:18836069, PubMed:21422164). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (PubMed:26245379). Interacts with PPL; the interaction disrupts agonist-mediated G protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (PubMed:18836069). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (PubMed:15827571, PubMed:17725581, PubMed:18439408, PubMed:21153910). Isoform 9 interacts with GRPR (PubMed:22000021). Interacts with SIGMAR1 (PubMed:28350844)

• Min B.H. et al. Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene. — Proc. Natl. Acad. Sci. U.S.A. (1994)
• Rossi G.C. et al. Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor. — FEBS Lett. (1995)
• Kaufman D.L. et al. Characterization of the murine mu opioid receptor gene. — J. Biol. Chem. (1995)
• Pan Y.X. et al. Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. — Mol. Pharmacol. (1999)
• Pan Y.-X. et al. Identification and characterization of a mouse spliced mu-opioid receptor isoform (MOR-1A). (JUL-)
• Pan Y.X. et al. Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F. — FEBS Lett. (2000)
• Ikeda K. et al. The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice. — J. Neurosci. (2001)
• Pan Y.X. et al. Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. — Proc. Natl. Acad. Sci. U.S.A. (2001)