Recombinant Mouse NELL2-interacting cell ontogeny regulator 1 (Nicol1), Mus musculus (Mouse), E.coli, C-terminal 6xHis-tagged, 13.8kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse NELL2-interacting cell ontogeny regulator 1 (Nicol1)

Recombinant Mouse NELL2-interacting cell ontogeny regulator 1 (Nicol1) — mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Purity >95%.

SKU: BCRECP-003873 Category:
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Product Specifications

Product SkuBCRECP-003873
Product DescriptionRecombinant Mouse NELL2-interacting cell ontogeny regulator 1 (Nicol1) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 29-90aa. [Accession | Q3UR78].
Uniprot No.Q3UR78
Gene NamesNicol1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region29-90aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight13.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2.

Biological Context

Subcellular Location: Secreted; Cytoplasm, perinuclear region
Tissue Specificity: Expression is enriched in both male and female reproductive organs, including the testis, epididymis, seminal vesicles, coagulating glands, ovary and uterus, and in various non-reproductive organs such as brain, thymus and liver. In testis, expressed in both germ cells and Sertoli cells. Also expressed at low levels in the kidney. Expressed during neocortex and cerebellum development

Product Specifications

Recombinant Mouse NELL2-interacting cell ontogeny regulator 1 (Nicol1) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 29-90aa, with C-terminal 6xHis-tagged tag, molecular weight 13.8kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production (PubMed:38625739). Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation (PubMed:38625739). Also binds to the 3'-UTR of ACTA2 (PubMed:38625739). Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation (PubMed:37095084)

Subcellular Location

Secreted; Cytoplasm, perinuclear region

Tissue Specificity

Expression is enriched in both male and female reproductive organs, including the testis, epididymis, seminal vesicles, coagulating glands, ovary and uterus, and in various non-reproductive organs such as brain, thymus and liver (PubMed:37095084). In testis, expressed in both germ cells and Sertoli cells (PubMed:37095084). Also expressed at low levels in the kidney (PubMed:38625739). Expressed during neocortex and cerebellum development (PubMed:21287218)

Subunit

Interacts with NELL2; triggers epididymal differentiation (PubMed:37095084). Interacts with cell surface receptor TFRC; the interaction mediates uptake of NICOL1 into fibroblasts (PubMed:38625739)

Gene: Nicol1  |  Organism: Mus musculus  |  Synonyms: NELL2-interacting cofactor for lumicrine signaling

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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