Recombinant Mouse P2X purinoceptor 4 (P2rx4), partial Protein, Mus musculus (Mouse), in vitro E.coli expression system, N-terminal 6xHis-SUMO-tagged, 47.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse P2X purinoceptor 4 (P2rx4), partial Protein

Recombinant Mouse P2X purinoceptor 4 (P2rx4), partial Protein — ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Purity >90%.

SKU: BCRECP-00685TM Category:
Online Inquiry →

Product Specifications

Uniprot No.Q9JJX6
Gene NamesP2rx4
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region55-338aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight47.5kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Lysosome membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Mouse P2X purinoceptor 4 (P2rx4), partial Protein is a recombinant protein from Mus musculus (Mouse), expressed in in vitro E.coli expression system, covering amino acids 55-338aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 47.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:26456657, PubMed:35119925). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (PubMed:35119925). Also participates in basal T-cell activity without TCR/CD3 stimulation (PubMed:35119925). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway (PubMed:17299767). Could also function as an ATP-gated cation channel of lysosomal membranes (PubMed:27477609)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Lysosome membrane (Multi-pass membrane protein)

Subunit

Functional P2RXs are organized as homomeric and heteromeric trimers. Functional P2XRs are organized as homomeric and heteromeric trimers. Forms heterotrimer with P2RX1 (By similarity). Interacts with P2RX7 (via C-terminus); this interaction is functional only in the presence of ATP (PubMed:26456657). Forms heterotrimer with P2RX4; functional differences between homomeric P2RX4 and P2RX4/6 heterotrimer are minor (By similarity). Interacts with AP1M2 (By similarity)

Gene: P2rx4  |  Organism: Mus musculus  |  Synonyms: ATP receptor; Purinergic receptor
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top