Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2), Mus musculus (Mouse), Yeast, N-terminal 6xHis-tagged, 59.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2)

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) — Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. Purity >85%.

SKU: BCRECP-002891 Category:
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Product Specifications

Product SkuBCRECP-002891
Product DescriptionRecombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 22-531aa. [Accession | Q9D733].
Uniprot No.Q9D733
Gene NamesGp2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region22-531aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight59.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.

Biological Context

Subcellular Location: Zymogen granule membrane (Lipid-anchor, GPI-anchor); Secreted; Cell membrane (Lipid-anchor, GPI-anchor); Apical cell membrane (Lipid-anchor, GPI-anchor); Membrane raft (Lipid-anchor, GPI-anchor); Endosome
Tissue Specificity: Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine

Product Specifications

Recombinant Mouse Pancreatic secretory granule membrane major glycoprotein GP2 (Gp2) is a recombinant protein from Mus musculus (Mouse), expressed in Yeast, covering amino acids 22-531aa, with N-terminal 6xHis-tagged tag, molecular weight 59.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response

Subcellular Location

Zymogen granule membrane (Lipid-anchor, GPI-anchor); Secreted; Cell membrane (Lipid-anchor, GPI-anchor); Apical cell membrane (Lipid-anchor, GPI-anchor); Membrane raft (Lipid-anchor, GPI-anchor); Endosome

Tissue Specificity

Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine

Subunit

Interacts with SYCN. Interacts with bacterial adhesin fimH

Gene: Gp2  |  Organism: Mus musculus  |  Synonyms: Pancreatic zymogen granule membrane protein GP-2

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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