Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 15.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1)

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) — Promotes activation of caspases and apoptosis. Purity >85%.

SKU: BCRECP-004118 Category:
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Product Specifications

Product SkuBCRECP-004118
Product DescriptionRecombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-103aa. [Accession | Q9JM54].
Uniprot No.Q9JM54
Gene NamesPmaip1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-103aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight15.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney

Product Specifications

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-103aa, with N-terminal 6xHis-tagged tag, molecular weight 15.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1

Subcellular Location

Mitochondrion

Tissue Specificity

Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney

Subunit

Interacts with MCL1 (PubMed:10807576, PubMed:15694340, PubMed:15901672, PubMed:17389404). Interacts with BCL2A1 (By similarity). Interacts with BAX (By similarity). Interacts with BCL2L10 (By similarity)

Gene: Pmaip1  |  Organism: Mus musculus  |  Synonyms: Protein Noxa
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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