Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1), Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 15.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1)

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) — Promotes activation of caspases and apoptosis. Purity >85%.

SKU: BCRECP-004118 Category:
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Product Specifications

Product SkuBCRECP-004118
Product DescriptionRecombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-103aa. [Accession | Q9JM54].
Uniprot No.Q9JM54
Gene NamesPmaip1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-103aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight15.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure.

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney

Product Specifications

Recombinant Mouse Phorbol-12-myristate-13-acetate-induced protein 1 (Pmaip1) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-103aa, with N-terminal 6xHis-tagged tag, molecular weight 15.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1

Subcellular Location

Mitochondrion

Tissue Specificity

Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level). Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney

Subunit

Interacts with MCL1 (PubMed:10807576, PubMed:15694340, PubMed:15901672, PubMed:17389404). Interacts with BCL2A1 (By similarity). Interacts with BAX (By similarity). Interacts with BCL2L10 (By similarity)

Gene: Pmaip1  |  Organism: Mus musculus  |  Synonyms: Protein Noxa
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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