Recombinant Mouse Platelet-derived growth factor D (Pdgfd)

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix

Subcellular Location

Secreted

Tissue Specificity

Expressed at high levels in developing heart, lung, kidney and some muscle derivatives. Moderately expressed in liver, brain and testis. In the kidney, localized to glomerular mesangial cells and vascular smooth muscle cells. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, expressed in interstitial cells at day 4, with an increased to maximal expression at day 14

Subunit

Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity)

• LaRochelle W.J. et al. PDGF D, a novel protease-activated growth factor. — Nat. Cell Biol. (2001)
• Zhuo Y. et al. A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function. — Biochem. Biophys. Res. Commun. (2003)
• Carninci P. et al. The transcriptional landscape of the mammalian genome. — Science (2005)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Bergsten E. et al. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. — Nat. Cell Biol. (2001)
• LaRochelle W.J. et al. Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer. — Cancer Res. (2002)
• Tallquist M. et al. PDGF signaling in cells and mice. — Cytokine Growth Factor Rev. (2004)
• Hudkins K.L. et al. Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy. — J. Am. Soc. Nephrol. (2004)