Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 32.9kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial — Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. Purity >95%.

SKU: BCRECP-004049 Category:
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Product Specifications

Product SkuBCRECP-004049
Product DescriptionRecombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 776-1034aa. [Accession | Q8VIK5].
Uniprot No.Q8VIK5
Gene NamesPear1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region776-1034aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis.

Biological Context

Subcellular Location: Cell membrane (Single-pass membrane protein); Cell projection, lamellipodium
Tissue Specificity: Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level). Strongly expressed in kidney and heart. Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach. Expressed in hematopoietic stem progenitor cells

Product Specifications

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 776-1034aa, with N-terminal 6xHis-tagged tag, molecular weight 32.9kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (PubMed:17226770)

Subcellular Location

Cell membrane (Single-pass membrane protein); Cell projection, lamellipodium

Tissue Specificity

Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level) (PubMed:17226770). Strongly expressed in kidney and heart (PubMed:17226770). Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach (PubMed:17226770). Expressed in hematopoietic stem progenitor cells (PubMed:17226770)

Subunit

Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation (By similarity). Interacts (via extracellular domain) with SVEP1 (By similarity)

Gene: Pear1  |  Organism: Mus musculus  |  Synonyms: Jagged and Delta protein; Multiple epidermal growth factor-like domains protein 12
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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