Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 32.9kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial — Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. Purity >95%.

SKU: BCRECP-004049 Category:
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Product Specifications

Product SkuBCRECP-004049
Product DescriptionRecombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 776-1034aa. [Accession | Q8VIK5].
Uniprot No.Q8VIK5
Gene NamesPear1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region776-1034aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling. May be involved in the early stages of hematopoiesis.

Biological Context

Subcellular Location: Cell membrane (Single-pass membrane protein); Cell projection, lamellipodium
Tissue Specificity: Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level). Strongly expressed in kidney and heart. Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach. Expressed in hematopoietic stem progenitor cells

Product Specifications

Recombinant Mouse Platelet endothelial aggregation receptor 1 (Pear1), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 776-1034aa, with N-terminal 6xHis-tagged tag, molecular weight 32.9kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (PubMed:17226770)

Subcellular Location

Cell membrane (Single-pass membrane protein); Cell projection, lamellipodium

Tissue Specificity

Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level) (PubMed:17226770). Strongly expressed in kidney and heart (PubMed:17226770). Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach (PubMed:17226770). Expressed in hematopoietic stem progenitor cells (PubMed:17226770)

Subunit

Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation (By similarity). Interacts (via extracellular domain) with SVEP1 (By similarity)

Gene: Pear1  |  Organism: Mus musculus  |  Synonyms: Jagged and Delta protein; Multiple epidermal growth factor-like domains protein 12
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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