Recombinant Mouse Sex-determining region Y protein (Sry), partial, Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 21.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Mouse Sex-determining region Y protein (Sry), partial

Recombinant Mouse Sex-determining region Y protein (Sry), partial — Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation. Purity >90%.

SKU: BCRECP-004484 Category:
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Product Specifications

Product SkuBCRECP-004484
Product DescriptionRecombinant Mouse Sex-determining region Y protein (Sry) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-144aa. [Accession | Q05738].
Uniprot No.Q05738
Gene NamesSry
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-144aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight21.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation. Not necessary and sufficient for initiating male sex determination.

Biological Context

Subcellular Location: Nucleus speckle; Cytoplasm; Nucleus
Tissue Specificity: Expressed in gonadal somatic pre-Sertoli cells. While it is expressed at lower level compared to isoform Sry-S, this form is more stable and constitutes the predominant protein product of the Sry locus in XY gonads (at protein level)

Product Specifications

Recombinant Mouse Sex-determining region Y protein (Sry), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-144aa, with N-terminal 6xHis-tagged tag, molecular weight 21.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation (PubMed:33004521). Not necessary and sufficient for initiating male sex determination (PubMed:33004521)

Subcellular Location

Nucleus speckle; Cytoplasm; Nucleus

Tissue Specificity

Expressed in gonadal somatic pre-Sertoli cells (PubMed:33004521). While it is expressed at lower level compared to isoform Sry-S, this form is more stable and constitutes the predominant protein product of the Sry locus in XY gonads (at protein level) (PubMed:33004521)

Subunit

Interacts with KPNB1, ZNF208 isoform KRAB-O, PARP1 and SLC9A3R2 (PubMed:11535586, PubMed:15469996, PubMed:16166090, PubMed:16904257). The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form (PubMed:11535586). Interaction with PARP1 impaired its DNA-binding activity (PubMed:16904257). Interacts with CALM, EP300, HDAC3 and WT1 (By similarity). The interaction with EP300 modulates its DNA-binding activity (By similarity)

Gene: Sry  |  Organism: Mus musculus  |  Synonyms: Testis-determining factor
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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