Recombinant Mouse Somatostatin (Sst), partial

Function

May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892). This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648). May regulate cardiac contractile function (PubMed:25012062). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity). Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity)

Subcellular Location

Secreted

Tissue Specificity

In the pancreas, somatostatin is expressed in delta cells of the islets of Langerhans. In the stomach, it is expressed in parietal cells of oxyntic mucosa and in the small intestine, it is found in the villus (at protein level) (PubMed:18753129). Neuronostatin is expressed in the pancreas in delta cells of the islets of Langerhans, as well as in the stomach, in parietal cells of oxyntic mucosa and in the small intestine, in the villus (at protein level) (PubMed:18753129)

• Fuhrmann G. et al. Nucleotide sequence of the mouse preprosomatostatin gene. — Nucleic Acids Res. (1990)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Samson W.K. et al. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions. — J. Biol. Chem. (2008)
• Salvatori A.S. et al. Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic alpha-cell. — Am. J. Physiol. (2014)
• Zhu X. et al. Neuronostatin attenuates myocardial contractile function through inhibition of sarcoplasmic reticulum Ca2+-ATPase in murine heart. — Cell. Physiol. Biochem. (2014)
• Elrick M.M. et al. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells. — Am. J. Physiol. (2016)