Recombinant Mouse XIAP-associated factor 1 (Xaf1), Mus musculus (Mouse), E.coli, C-terminal 6xHis-tagged, 38.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse XIAP-associated factor 1 (Xaf1)

Recombinant Mouse XIAP-associated factor 1 (Xaf1) — Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Purity >85%.

SKU: BCRECP-004754 Category:
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Product Specifications

Product SkuBCRECP-004754
Product DescriptionRecombinant Mouse XIAP-associated factor 1 (Xaf1) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 1-273aa. [Accession | Q5NBU8].
Uniprot No.Q5NBU8
Gene NamesXaf1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-273aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 6xHis-tagged
Molecular weight38.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation.

Biological Context

Subcellular Location: Cytoplasm; Nucleus; Mitochondrion

Product Specifications

Recombinant Mouse XIAP-associated factor 1 (Xaf1) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-273aa, with C-terminal 6xHis-tagged tag, molecular weight 38.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity)

Subcellular Location

Cytoplasm; Nucleus; Mitochondrion

Subunit

Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation. Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling (By similarity)

Gene: Xaf1  |  Organism: Mus musculus  |  Synonyms: BIRC4-binding protein

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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