Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial, Sus scrofa (Pig), E.coli, N-terminal 6xHis-tagged, 28.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial

Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial — Receptor for both interleukin 4 and interleukin 13. Purity >85%.

SKU: BCRECP-003163 Categories: ,
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Product Specifications

Product SkuBCRECP-003163
Product DescriptionRecombinant Pig Interleukin-4 receptor subunit alpha (IL4R) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 33-240aa. [Accession | Q863Z5].
Uniprot No.Q863Z5
Gene NamesIL4R
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region33-240aa
SpeciesSus scrofa (Pig)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Pig Interleukin-4 receptor subunit alpha (IL4R), partial is a recombinant protein from Sus scrofa (Pig), expressed in E.coli, covering amino acids 33-240aa, with N-terminal 6xHis-tagged tag, molecular weight 28.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity)

Subcellular Location

Membrane (Single-pass type I membrane protein)

Subunit

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Interacts with JAK3. Interacts with CLM1. Interacts with IL13RA2

Gene: IL4R  |  Organism: Sus scrofa

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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