Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial, Sus scrofa (Pig), E.coli, C-terminal 6xHis-tagged, 25.1kDa, purity >95% as determined by SDS-PAGE.

Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial

Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial — G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Purity >95%.

SKU: BCRECP-004198 Category:
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Product Specifications

Product SkuBCRECP-004198
Product DescriptionRecombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 27-184aa. [Accession | P50133].
Uniprot No.P50133
Gene NamesPTH1R
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region27-184aa
SpeciesSus scrofa (Pig)
Tag InfoC-terminal 6xHis-tagged
Molecular weight25.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Pig Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R), partial is a recombinant protein from Sus scrofa (Pig), expressed in E.coli, covering amino acids 27-184aa, with C-terminal 6xHis-tagged tag, molecular weight 25.1kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:8688470). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Subunit

Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer

Gene: PTH1R  |  Organism: Sus scrofa  |  Synonyms: PTH/PTHrP type I receptor; Parathyroid hormone 1 receptor

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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