Recombinant Pongo abelii 2,3-cyclic-nucleotide 3-phosphodiesterase (CNP), Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 54.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Pongo abelii 2,3-cyclic-nucleotide 3-phosphodiesterase (CNP)

Recombinant Pongo abelii 2,3-cyclic-nucleotide 3-phosphodiesterase (CNP) — Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2′,3′-cyclic nucleotides to 2′-nucleotides. Purity >90%.

SKU: BCRECP-002403 Categories: ,
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Product Specifications

Product SkuBCRECP-002403
Product DescriptionRecombinant Pongo abelii 2,3-cyclic-nucleotide 3-phosphodiesterase (CNP) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-418aa. [Accession | Q5RFD0].
Uniprot No.Q5RFD0
Gene NamesCNP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-418aa
SpeciesPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight54.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions.

Biological Context

Subcellular Location: Melanosome; Mitochondrion

Product Specifications

Recombinant Pongo abelii 2,3-cyclic-nucleotide 3-phosphodiesterase (CNP) is a recombinant protein from Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii), expressed in E.coli, covering amino acids 1-418aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 54.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions

Subcellular Location

Melanosome; Mitochondrion

Subunit

Exists as monomers and homodimers

Gene: CNP  |  Organism: Pongo abelii

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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