Recombinant Rat C-C motif chemokine 7 protein (Ccl7), Rattus norvegicus (Rat), E.Coli, Tag-Free, 8.5 kDa, purity >>95% as determined by SDS-PAGE.
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Recombinant Rat C-C motif chemokine 7 protein (Ccl7)

Recombinant Rat C-C motif chemokine 7 protein (Ccl7) — Chemotactic factor that plays an important role in immune regulation. Purity >95%.

SKU: BCACP-000828 Categories: ,
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Product SKUBCACP-000828
Product DescriptionRecombinant Rat C-C motif chemokine 7 protein (Ccl7) protein is expressed from E.Coli with Tag-Free. It contains 24-97aa. [Accession | Q9QXY8].
Uniprot No.Q9QXY8
Gene NamesCcl7
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-97aa
SpeciesRattus norvegicus (Rat)
Tag InfoTag-Free
Molecular weight8.5 kDa
ActivityFully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 10-100 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCcl7; Mcp3; Scya7C-C motif chemokine 7; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; Small-inducible cytokine A7

Function

Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Rat C-C motif chemokine 7 protein (Ccl7) is a recombinant protein from Rattus norvegicus (Rat), expressed in E.Coli, covering amino acids 24-97aa, with Tag-Free tag, molecular weight 8.5 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 10-100 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Chemotactic factor that plays an important role in immune regulation. Attracts monocytes, eosinophils, basophils, and T-cells to sites of inflammation or infection. Upon binding to various chemokine receptors including CCR1, CCR2, CCR3, and CCR5, facilitates immune cell migration by guiding them to infected tissues. Interacts with CCR2 to facilitate the release of monocytes from the bone marrow into the bloodstream, maintaining monocyte homeostasis. In turn, monocytes recruited to inflamed or injured tissues can differentiate into macrophages or dendritic cells, which are essential for immune defense and tissue repair. Through CCR1, contributes to macrophage polarization via NF-kappa-B activation which leads to the release of inflammatory factors. In the trigeminal ganglion neurons, activates ERK via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. Additionally, modulates the early immune response in the skin, preventing pathogen dissemination while maintaining cutaneous immune control

Subcellular Location

Secreted

Subunit

Monomer. Interacts with TNFAIP6 (via Link domain)

Gene: Ccl7  |  Organism: Rattus norvegicus  |  Synonyms: Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; Small-inducible cytokine A7

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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