Recombinant Rat Dystrophin (Dmd), partial — Anchors the extracellular matrix to the cytoskeleton via F-actin. Purity >90%.
| Product Sku | BCRECP-002546 |
| Product Description | Recombinant Rat Dystrophin (Dmd) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-240aa. [Accession | P11530]. |
| Uniprot No. | P11530 |
| Gene Names | Dmd |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Expression System | Yeast |
| Expression Region | 1-240aa |
| Species | Rattus norvegicus (Rat) |
| Tag Info | C-terminal 6xHis-tagged |
| Molecular weight | 29.1kDa |
| Activity | Please contact us to obtain bioactivity data. |
| Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Research Areas | Signal Transduction |
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan.
Recombinant Rat Dystrophin (Dmd), partial — Anchors the extracellular matrix to the cytoskeleton via F-actin. Purity >90%. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Please contact us to obtain bioactivity data.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission
Cell membrane, sarcolemma (Peripheral membrane protein); Cytoplasm, cytoskeleton; Postsynaptic cell membrane
Strongly expressed in skeletal muscle and weak expression observed in newborn brain which increases in adult brain
Interacts with SYNM (By similarity). Interacts with the syntrophins SNTG1 and SNTG2. Interacts with KRT19. Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex. Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity). Interacts with SYNM; SNTA1 and SNTB1. Interacts with CMYA5. Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells. Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Interacts with DTNB (PubMed:10545507). Interacts with PGM5; the interaction is direct (By similarity). Interacts with NOS1; localizes NOS1 to sarcolemma in muscle cells (By similarity)
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
