Recombinant Rat FAD-linked sulfhydryl oxidase ALR (Gfer), Rattus norvegicus (Rat), E.coli, N-terminal 6xHis-SUMO-tagged, 38.8kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Rat FAD-linked sulfhydryl oxidase ALR (Gfer)

Recombinant Rat FAD-linked sulfhydryl oxidase ALR (Gfer) — FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial inter… Purity >90%.

SKU: BCRECP-002842 Categories: ,
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Product Specifications

Product SkuBCRECP-002842
Product DescriptionRecombinant Rat FAD-linked sulfhydryl oxidase ALR (Gfer) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-198aa. [Accession | Q63042].
Uniprot No.Q63042
Gene NamesGfer
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-198aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight38.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.

Biological Context

Subcellular Location: Mitochondrion intermembrane space; Mitochondrion

Product Specifications

Recombinant Rat FAD-linked sulfhydryl oxidase ALR (Gfer) is a recombinant protein from Rattus norvegicus (Rat), expressed in E.coli, covering amino acids 1-198aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 38.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis

Subcellular Location

Mitochondrion intermembrane space; Mitochondrion

Subunit

Homodimer; disulfide-linked (PubMed:12717032, PubMed:22948913). Interacts with CHCHD4/MIA40 (By similarity)

Gene: Gfer  |  Organism: Rattus norvegicus  |  Synonyms: Augmenter of liver regeneration
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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