Recombinant Rat Gremlin-1 (Grem1), Rattus norvegicus (Rat), Baculovirus, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 22.2kDa, purity >85% as determined by SDS-PAGE.

Recombinant Rat Gremlin-1 (Grem1)

Recombinant Rat Gremlin-1 (Grem1) — Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH… Purity >85%.

SKU: BCRECP-002913 Category:
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Product Specifications

Product SkuBCRECP-002913
Product DescriptionRecombinant Rat Gremlin-1 (Grem1) Protein is expressed from Baculovirus with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 25-184aa. [Accession | O35793].
Uniprot No.O35793
Gene NamesGrem1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region25-184aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight22.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro).

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine

Product Specifications

Recombinant Rat Gremlin-1 (Grem1) is a recombinant protein from Rattus norvegicus (Rat), expressed in Baculovirus, covering amino acids 25-184aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 22.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (PubMed:15528323). Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed

Subcellular Location

Secreted

Tissue Specificity

Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine

Subunit

Homodimer; can also form homooligomers. Interacts with BMP2; can form higher oligomers with BMP2 (By similarity). Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner (PubMed:15528323)

Gene: Grem1  |  Organism: Rattus norvegicus  |  Synonyms: Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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