Recombinant Rat Integrin beta-4 (Itgb4), partial Protein, Rattus norvegicus (Rat), in vitro E.coli expression system, N-terminal 6xHis-tagged, 80.2kDa, purity >85% as determined by SDS-PAGE.

Recombinant Rat Integrin beta-4 (Itgb4), partial Protein

Recombinant Rat Integrin beta-4 (Itgb4), partial Protein — Integrin alpha-6/beta-4 is a receptor for laminin. Purity >85%.

SKU: BCRECP-00707TM Category:
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Product Specifications

Uniprot No.Q64632
Gene NamesItgb4
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region28-713aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 6xHis-tagged
Molecular weight80.2kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell membrane (Lipid-anchor); Cell junction, hemidesmosome

Product Specifications

Recombinant Rat Integrin beta-4 (Itgb4), partial Protein is a recombinant protein from Rattus norvegicus (Rat), expressed in in vitro E.coli expression system, covering amino acids 28-713aa, with N-terminal 6xHis-tagged tag, molecular weight 80.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell membrane (Lipid-anchor); Cell junction, hemidesmosome

Subunit

Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2 (By similarity). Interacts with TMEM268; this interaction prevents ITGB4 degradation (By similarity). Interacts (via C-terminus) with ARHGEF40 (via central region); the interaction may facilitate ITGB4 localization to hemidesmosomes and act as a linker to anchor keratin filaments to ITGB4 in hemidesmosomes (By similarity)

Gene: Itgb4  |  Organism: Rattus norvegicus  |  Synonyms: GP150

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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