Recombinant Rat Interleukin-1 receptor accessory protein (Il1rap), partial (Active) — Coreceptor for IL1RL2 in the IL-36 signaling system. Purity >95%.
| Product SKU | BCACP-000428 |
| Product Description | Recombinant Rat Interleukin-1 receptor accessory protein (Il1rap) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 21-367aa. [Accession | Q63621]. |
| Uniprot No. | Q63621 |
| Gene Names | Il1rap |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Expression System | Mammalian cell |
| Expression Region | 21-367aa |
| Species | Rattus norvegicus (Rat) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 41.4 kDa |
| Activity | Measured by its binding ability in a functional ELISA.Immobilized Human NTN1 at 2 μg/mL can bind Anti-NTN1 recombinant antibody .The EC50 is 26.43-30.77 ng/mL. |
| Buffer | Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Alternative Names | Interleukin-1 receptor accessory protein; EC:3.2.2.6; IL-1 receptor accessory protein; IL-1RAcP; Il1rap |
Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system.
Recombinant Rat Interleukin-1 receptor accessory protein (Il1rap), partial (Active) — Coreceptor for IL1RL2 in the IL-36 signaling system. Purity >95%. Suitable for ELISA and Western Blot applications. Explore more Interleukin proteins →
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human NTN1 at 2 μg/mL can bind Anti-NTN1 recombinant antibody .The EC50 is 26.43-30.77 ng/mL.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)
Membrane (Single-pass type I membrane protein)
Highly expressed in hypothalamus, in the dentate gyrus of hippocampus, cerebral cortex, cerebellum, liver and lung
The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex (By similarity). Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity)
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
