Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1), Rattus norvegicus (Rat), E.coli, N-terminal 6xHis-SUMO-tagged, 58.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1)

Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1) — Serine protease inhibitor. Purity >90%.

SKU: BCRECP-004403 Category:
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Product Specifications

Product SkuBCRECP-004403
Product DescriptionRecombinant Rat Plasminogen activator inhibitor 1 (Serpine1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 24-402aa. [Accession | P20961].
Uniprot No.P20961
Gene NamesSerpine1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-402aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight58.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1) is a recombinant protein from Rattus norvegicus (Rat), expressed in E.coli, covering amino acids 24-402aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 58.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity)

Subcellular Location

Secreted

Subunit

Forms a heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Interacts with PPP1CB. In complex with PLAU/uPA, interacts with PLAUR/uPAR (By similarity). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (By similarity). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (By similarity). Interacts with PLAT/tPA (By similarity). Also interacts with SORL1, when complexed to PLAT/tPA (By similarity)

Gene: Serpine1  |  Organism: Rattus norvegicus  |  Synonyms: Endothelial plasminogen activator inhibitor; Serpin E1

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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