Recombinant Rat Serum albumin (Alb)

Function

Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)

Subcellular Location

Secreted

Tissue Specificity

Plasma

Subunit

Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB

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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Strauss A.W. et al. Rat liver pre-proalbumin: complete amino acid sequence of the pre-piece. Analysis of the direct translation product of albumin messenger RNA. — J. Biol. Chem. (1977)
• Peters T. Jr. et al. The biosynthesis of rat serum albumin. Composition and properties of the intracellular precursor, proalbumin. — J. Biol. Chem. (1980)
• Isemura S. et al. Amino acid sequences of fragments I and II obtained by cyanogen bromide cleavage of rat serum albumin. — J. Biochem. (1978)
• Carraway R.E. et al. Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). — J. Biol. Chem. (1987)
• Lubec G. et al. PubMed: CI-EO9MMJEOMV7EQ (JUL-)
• Isemura S. et al. Fragmentation of rat serum albumin by cyanogen bromide cleavage and the amino acid sequences of four fragments. — J. Biochem. (1976)