Recombinant Rat Thyroglobulin (Tg), partial, Rattus norvegicus (Rat), E.coli, N-terminal 6xHis-SUMO-tagged, 48.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Rat Thyroglobulin (Tg), partial

Recombinant Rat Thyroglobulin (Tg), partial — Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Purity >90%.

SKU: BCRECP-004550 Category:
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Product Specifications

Product SkuBCRECP-004550
Product DescriptionRecombinant Rat Thyroglobulin (Tg) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 21-300aa. [Accession | P06882].
Uniprot No.P06882
Gene NamesTg
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-300aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight48.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Specifically expressed in the thyroid gland
Disease Association: [Defects in Tg are a cause of a form of hypothyroidism in rdw rat]

Product Specifications

Recombinant Rat Thyroglobulin (Tg), partial is a recombinant protein from Rattus norvegicus (Rat), expressed in E.coli, covering amino acids 21-300aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 48.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity)

Subcellular Location

Secreted

Disease Association

[Defects in Tg are a cause of a form of hypothyroidism in rdw rat]

Tissue Specificity

Specifically expressed in the thyroid gland

Subunit

Monomer (By similarity). Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus (By similarity). Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen (By similarity)

Gene: Tg  |  Organism: Rattus norvegicus

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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