Recombinant Reovirus type 3 Outer capsid protein sigma-3 (S4), Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3), Baculovirus, C-terminal 6xHis-tagged, 46.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Reovirus type 3 Outer capsid protein sigma-3 (S4)

Recombinant Reovirus type 3 Outer capsid protein sigma-3 (S4) — recombinant protein from Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3), expressed in Baculovirus. Purity >90%.

SKU: BCRECP-004354 Categories: ,
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Product Specifications

Product SkuBCRECP-004354
Product DescriptionRecombinant Reovirus type 3 Outer capsid protein sigma-3 (S4) Protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 1-365aa. [Accession | P03527].
Uniprot No.P03527
Gene NamesS4
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region1-365aa
SpeciesReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)
Tag InfoC-terminal 6xHis-tagged
Molecular weight46.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.

Biological Context

Subcellular Location: Virion; Host cytoplasm; Host nucleus

Product Specifications

Recombinant Reovirus type 3 Outer capsid protein sigma-3 (S4) is a recombinant protein from Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3), expressed in Baculovirus, covering amino acids 1-365aa, with C-terminal 6xHis-tagged tag, molecular weight 46.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3

Subcellular Location

Virion; Host cytoplasm; Host nucleus

Subunit

Heterohexamer of three sigma-3 and three Mu-1 protein (By similarity). The RNA-binding form is probably a homodimer (PubMed:11230122). Interacts with 2 molecules of the host receptor RTN4R/NGR1; this interaction allows the virus entry into the cell (PubMed:37276413). Interacts with the host chaperones of the TRIC complex and Prefoldin; this interactions are involved in folding sigma-3 and promoting its assembly into higher-order oligomers for integration into mature reovirus particles (PubMed:33836586). Sigma-3 bridges two hemispheres of the TRiC complex with its oligomerization domain oriented toward the center of the folding chamber (PubMed:33836586)

Gene: S4  |  Organism: Reovirus type 3 (strain Dearing)
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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