Recombinant Salmonella typhimurium Protein prgI (prgI), Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), E.coli, N-terminal 6xHis-SUMO-tagged, 24.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Salmonella typhimurium Protein prgI (prgI)

Recombinant Salmonella typhimurium Protein prgI (prgI) — During infection, can induce innate immune responses. Purity >90%.

SKU: BCRECP-004160 Category:
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Product Specifications

Product SkuBCRECP-004160
Product DescriptionRecombinant Salmonella typhimurium Protein prgI (prgI) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-80aa. [Accession | P41784].
Uniprot No.P41784
Gene NamesprgI
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-80aa
SpeciesSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight24.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

During infection, can induce innate immune responses. The needle proteins interact with host TLR2 or TLR4, and induce signaling by NF-kappa-B and/or AP-1. This activation is MyD88 dependent and results in increased expression of cytokines, including TNF, IL-6 and IL-8.

Biological Context

Subcellular Location: Secreted; Cell surface

Product Specifications

Recombinant Salmonella typhimurium Protein prgI (prgI) is a recombinant protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720), expressed in E.coli, covering amino acids 1-80aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 24.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

During infection, can induce innate immune responses (PubMed:24643544). The needle proteins interact with host TLR2 or TLR4, and induce signaling by NF-kappa-B and/or AP-1 (PubMed:24643544). This activation is MyD88 dependent and results in increased expression of cytokines, including TNF, IL-6 and IL-8 (PubMed:24643544)

Subcellular Location

Secreted; Cell surface

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569, PubMed:30242280, PubMed:31427728). This subunit polymerizes and forms the helical needle filament (PubMed:16501225, PubMed:20543831, PubMed:22699623, PubMed:30242280, PubMed:31260457, PubMed:31427728, PubMed:33750771, PubMed:34258394, PubMed:34706941). Interacts with the needle tip protein SipD/SctA (PubMed:21829362, PubMed:34706941). Interacts with the needle adapter protein PrgJ/SctI, the secretin InvG/SctC and the minor export apparatus protein SpaP/SctR (PubMed:33750771). In vitro, the needle protomer refolds spontaneously to extend the needle from the distal end (PubMed:20543831)

Gene: sctF1  |  Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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