Recombinant Simian immunodeficiency virus Protein Vpx (vpx), Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian immunodeficiency virus rhesus monkey), E.coli, N-terminal 6xHis-SUMO-tagged, 29.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Simian immunodeficiency virus Protein Vpx (vpx)

Recombinant Simian immunodeficiency virus Protein Vpx (vpx) — Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Purity >90%.

SKU: BCRECP-004743 Categories: , ,
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Product Specifications

Product SkuBCRECP-004743
Product DescriptionRecombinant Simian immunodeficiency virus Protein Vpx (vpx) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-112aa. [Accession | P11266].
Uniprot No.P11266
Gene Namesvpx
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-112aa
SpeciesSimian immunodeficiency virus (isolate K78) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight29.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host DCAF1.

Biological Context

Subcellular Location: Virion; Host nucleus

Product Specifications

Recombinant Simian immunodeficiency virus Protein Vpx (vpx) is a recombinant protein from Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian immunodeficiency virus rhesus monkey), expressed in E.coli, covering amino acids 1-112aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 29.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells (By similarity). Targets specific host proteins for degradation by the 26S proteasome (By similarity). Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host DCAF1 (PubMed:29891865). This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1 and TASOR (PubMed:29891865). In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). TASOR degradation inactivates the HUSH complex, counteracting the transcriptional repression of proviruses (PubMed:29891865)

Subcellular Location

Virion; Host nucleus

Subunit

Interacts with the P6 region of unprocessed GAG (By similarity). Interacts with host VPRBP/DCAF1, leading to change substrate specificity of the CUL4A-DDB1 E3 ligase complex (By similarity)

Gene: vpx  |  Organism: Simian immunodeficiency virus (isolate Mm251)  |  Synonyms: Viral protein X; X ORF protein

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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