Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial, Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 56.0kDa, purity >85% as determined by SDS-PAGE.
,

Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial

Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial — Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. Purity >85%.

SKU: BCRECP-003584 Categories: ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-003584
Product DescriptionRecombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 281-727aa. [Accession | P14336].
Uniprot No.P14336
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region281-727aa
SpeciesTick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight56.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway.

Biological Context

Subcellular Location: Host endoplasmic reticulum membrane (Peripheral membrane protein); Host nucleus

Product Specifications

Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial is a recombinant protein from Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus), expressed in E.coli, covering amino acids 281-727aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 56.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway

Subcellular Location

Host endoplasmic reticulum membrane (Peripheral membrane protein); Host nucleus

Subunit

Homodimer. Interacts with host STAT2; this interaction inhibits the phosphorylation of the latter, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation. Interacts with serine protease NS3. Interacts (via C-terminus) with host SCRIB (via PDZ3); this interaction targets NS5 to the cell membrane periphery and nucleus, thereby allowing efficient host nuclear STAT1 inhibition

Organism: Tick-borne encephalitis virus European subtype (strain Neudoerfl)
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top