Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1, Tityus serrulatus (Brazilian scorpion), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 14.3kDa, purity >85% as determined by SDS-PAGE.

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 — Voltage-gated sodium channels (Nav) gating-modifier. Purity >85%.

SKU: BCRECP-003602 Category:
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Product Specifications

Product SkuBCRECP-003602
Product DescriptionRecombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 21-81aa. [Accession | P15226].
Uniprot No.P15226
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-81aa
SpeciesTityus serrulatus (Brazilian scorpion)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight14.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 is a recombinant protein from Tityus serrulatus (Brazilian scorpion), expressed in E.coli, covering amino acids 21-81aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 14.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable) (PubMed:25862296). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements (PubMed:17698594, PubMed:19005548). Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity) (PubMed:17698594, PubMed:19005548, PubMed:25624450). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1) (PubMed:17698594, PubMed:21670206, PubMed:24989851, PubMed:25862296, PubMed:31012002, PubMed:9048656). Is highly active against both mammals and insects (PubMed:17118417, PubMed:21549737). Irreversibly modulates DmNav channels (PubMed:25862296). Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable). This toxin exhibits an antifungal activity against filamentous fungi (PubMed:28634472). In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of pro-inflammatory cytokines (PubMed:21549737). It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland (PubMed:10347806, PubMed:1993690, PubMed:9611141)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Organism: Tityus serrulatus  |  Synonyms: Beta-like toxin Ts1; PT-Mice-Ins-beta NaTx6.1; Tityustoxin VII; Toxin II-11; Toxin III-10; Toxin T2-IV; Toxin gamma; TsTX-I
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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