Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1, Tityus serrulatus (Brazilian scorpion), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 14.3kDa, purity >85% as determined by SDS-PAGE.

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 — Voltage-gated sodium channels (Nav) gating-modifier. Purity >85%.

SKU: BCRECP-003602 Category:
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Product Specifications

Product SkuBCRECP-003602
Product DescriptionRecombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 21-81aa. [Accession | P15226].
Uniprot No.P15226
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-81aa
SpeciesTityus serrulatus (Brazilian scorpion)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight14.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the venom gland

Product Specifications

Recombinant Tityus serrulatus Beta-mammal/insect toxin Ts1 is a recombinant protein from Tityus serrulatus (Brazilian scorpion), expressed in E.coli, covering amino acids 21-81aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 14.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable) (PubMed:25862296). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements (PubMed:17698594, PubMed:19005548). Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity) (PubMed:17698594, PubMed:19005548, PubMed:25624450). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1) (PubMed:17698594, PubMed:21670206, PubMed:24989851, PubMed:25862296, PubMed:31012002, PubMed:9048656). Is highly active against both mammals and insects (PubMed:17118417, PubMed:21549737). Irreversibly modulates DmNav channels (PubMed:25862296). Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable). This toxin exhibits an antifungal activity against filamentous fungi (PubMed:28634472). In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of pro-inflammatory cytokines (PubMed:21549737). It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland (PubMed:10347806, PubMed:1993690, PubMed:9611141)

Subcellular Location

Secreted

Tissue Specificity

Expressed by the venom gland

Organism: Tityus serrulatus  |  Synonyms: Beta-like toxin Ts1; PT-Mice-Ins-beta NaTx6.1; Tityustoxin VII; Toxin II-11; Toxin III-10; Toxin T2-IV; Toxin gamma; TsTX-I
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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