Recombinant Pongo pygmaeus Beta-defensin 126 (DEFB126), partial, Pongo pygmaeus (Bornean orangutan), Yeast, N-terminal GST-tagged, 31.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Pongo pygmaeus Beta-defensin 126 (DEFB126), partial

Recombinant Pongo pygmaeus Beta-defensin 126 (DEFB126), partial — Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Purity >90%.

SKU: BCRECP-002526 Category:
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Product Specifications

Product SkuBCRECP-002526
Product DescriptionRecombinant Pongo pygmaeus Beta-defensin 126 (DEFB126) Protein is expressed from Yeast with N-terminal GST-tagged. It contains 21-63aa. [Accession | A4H244].
Uniprot No.A4H244
Gene NamesDEFB126
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region21-63aa
SpeciesPongo pygmaeus (Bornean orangutan)
Tag InfoN-terminal GST-tagged
Molecular weight31.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx.

Product Specifications

Recombinant Pongo pygmaeus Beta-defensin 126 (DEFB126), partial — Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Purity >90%. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (By similarity)

Subcellular Location

Secreted

Subunit

Homodimer or homooligomer; disulfide-linked

Gene: DEFB126  |  Organism: Pongo pygmaeus  |  Synonyms: Defensin, beta 126

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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