Mouse anti-Human sapiens (Human) KRT13 Monoclonal Antibody

Function

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (PubMed:7493031). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity)

Disease Association

White sponge nevus 2 (WSN2) : A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta

Subunit

Heterodimers composed of one type I and one type II keratins; forms parallel coiled-coil heterodimers. Heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order keratin intermediate filaments

• Schulz P. et al. Sequence of a human keratin 13 specific cDNA encompassing coil 1B through the 3' end. — Biochem. Biophys. Res. Commun. (1989)
• Mischke D. et al. The N-, but not the C-terminal domains of human keratins 13 and 15 are closely related. — Nucleic Acids Res. (1989)
• Kuruc N. et al. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. — Differentiation (1989)
• Waseem A. et al. Isolation, sequence and expression of the gene encoding human keratin 13. — Gene (1998)
• Ota T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. — Nat. Genet. (2004)
• Suzuki Y. et al. PubMed: CI-5AVBODINQ93DF (APR-)
• Zody M.C. et al. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. — Nature (2006)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)