Recombinant Human Delta-like protein 3 (DLL3), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 6xHis-tagged, 51.5 kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Delta-like protein 3 (DLL3), partial (Active)

Recombinant Human Delta-like protein 3 (DLL3), partial (Active) — Inhibits primary neurogenesis. Purity >85%.

SKU: BCACP-000126 Category:
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Product SKUBCACP-000126
Product DescriptionRecombinant Human Delta-like protein 3 (DLL3) protein is expressed from Mammalian cell with C-terminal 6xHis-tagged. It contains 27-492aa. [Accession | Q9NYJ7].
Uniprot No.Q9NYJ7
Gene NamesDLL3
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-492aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight51.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized human VEGF165 ) at 2 μg/ml can bind human NRP1, the EC50 is 22.68-34.55 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Drosophila Delta homolog 3)(Delta3)

Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Disease Association: Spondylocostal dysostosis 1, autosomal recessive (SCDO1) : A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Delta-like protein 3 (DLL3), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-492aa, with C-terminal 6xHis-tagged tag, molecular weight 51.5 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)

Subcellular Location

Membrane (Single-pass type I membrane protein)

Disease Association

Spondylocostal dysostosis 1, autosomal recessive (SCDO1) : A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Can bind and activate Notch-1 or another Notch receptor

Gene: DLL3  |  Organism: Homo sapiens  |  Synonyms: Drosophila Delta homolog 3

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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